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3rd IRN I-GPCRNET - Programme   (05/05/2023)
Thème : Past Meeting & Workshop

 

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Scientific program : i-GPRC Net International meeting, Strasbourg – Illkirch 2023, October 25-27


 

Wednesday, October 25th, 2023

12:00 - Registration

14:15 - Opening

 

Session 1 : structural approaches and novel technologies

14:30 - Valérie Panneels (Division of Biology and Chemistry, Laboratory for Biomolecular Research, Paul Scherrer Institute, Villigen PSI, Switzerland).
First molecular events of vision, structure of ultrafast rhodopsin in movement captured with an X-ray free electron laser"

15:20 - Frank Bernhard - Frankfurt (Germany)
“Cryo-EM structures of cell-free synthesized human GPCR/G protein complexes in lipid environment”

15:45 - Hélène Déméné – Montpellier (France)
“Activation of the vasopressin V2 receptor seen by an integrative approach”

16:10 - Jenny Filor - Jena (Germany)
"Muscarinic acetylcholine receptors M2 and M4: interaction with β-arrestin and internalization to endosomes"

16:25 - Thibaut Laboute - Tours (France)
"Activation mechanisms of the orphan receptor GPR158"

16:40 - Nathalie Guillet (Revvity, France)
"New insights into GPCR functions and signaling by combining Revvity cell-based assays"

16:55 - Coffee break

17:30 - Claire de March (Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Université Paris-Saclay, Gif-sur-Yvette, France).
Toward the structural elucidation of mammalian odorant receptors

18:20 - Christoph Klenk – Zurich (Switzerland)
 “Tuning GPCR expression, stability and allostery by directed evolution in mammalian cells”

18:45 - Alexei Sirbu - Berlin (Germany)
"Functional modulation of ß2AR by cortical actin cytoskeleton"

19:00 - Pauline Raynaud - Nouzilly (France)
"Single domain intrabodies specifically targeting the follicle-stimulating hormone receptor (FSHR) affect receptor signalling and trafficking"

19:15 - Poster session (odd numbers) & Buffet

 

Thursday, October 26th, 2023

Session 2 : GPCRs, signalling & trafficking

09:00 - David J. Hodson (Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, UK).
Understanding GLP-1 and GIP receptor expression and signalling in the brain and periphery

09:50 - Olivier Lahuna – Paris (France)
“Intrication of the melatonergic pathway and the endocannabinoid system (ECS) through the Melatonin / Cannabinoid Type 1 Receptors (MT1/CB1) Heteromers“

10:15 - Coffee break

10:45 - Martha Sommer (ISAR Bioscience Institute, Munich-Planegg, Germany) 
The arrestins: evolutionary ‘old dogs’ performing complex tricks in GPCR/7TMR signal transduction

11:35 - Cornelius Krasel – Marburg (Germany)
“Mutations of lysines to arginines in the N-terminus of arrestins impairs arrestin binding to GPCRs by attenuating the release of the arrestin C-terminus”

12:00 - Junke Liu - Montpellier (France)
"Distinct roles of β-arrestins in GPCR endocytosis"

12:15 - Photo & Lunch

 

Session 3 : GPCRs and Physiology

14:30 - Simon M. Luckman (Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK).
“PrRP-GPR10 signalling in metabolism

15:20 - Sandra Lecat – Strasbourg (France)
“GPRASP1 is critical for airway hyperresponsiveness and tolerance following chronic beta2-adrenoceptors stimulation”

15:45 - Hélène Castel – Rouen (France)
“The urotensin II receptor instructs meningeal inflammation and macrophage-induced vasospasm during brain hemorrhagic stroke”

16:10 - Mona Reichel - Jena (Germany)
"The distinct roles of the GRK isoforms for the Endothelin-1 A receptor (ETAR) in ovarian cancer"

16:25 - Coffee break

17:00 - Cyril Rivat (Univ Montpellier, Montpellier, France; Inserm U-1298, Institut des Neurosciences de Montpellier, Montpellier, France).
FLT3 signaling in opioid side effects"

17:50 - Véronique Pons – Toulouse (France)
“Platelet P2Y1 receptor exhibits constitutive activity on both G protein signaling and b-arrestin 2 recruitment”

18:15 - Célia R. S. Garcia - São Paulo (Brasil)
“Decoding the role and signal transduction mechanism of GPCR-like proteins in malarial parasites”

18:40 - Julie Sanchez - Nottingham (UK)
"TRPing receptors – modulatory effect of TRP channels on GPCRs"

18:55 - General assembly

19:30 - Poster session (odd numbers) & Buffet

 

Friday, October 27th, 2023

Session 4 : Novel ligands/Drug development

09:00 - Matthias Schiedel (Department of Chemistry and Pharmacy
Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany)
"Targeting from the inside – New approaches for GPCR-based drug discovery”

09:50 - Dmitry B. Veprintsev – Nottingham (UK)
“Ligand-Directed Covalent Probes to study Cannabinoid Receptor 2 in Live Cells”

10:15 - Xavier Gómez-Santacana - Barcelona (Spain)
"A toolbox of photoswitchable allosteric modulators to control the activity of metabotropic glutamate receptors with light"

10:30 - Coffee break

11:00 - Philippe Rondard – Montpellier (France)
“Single domain antibodies targeting GPCRs as novel therapeutic agents for brain diseases“

11:25 - Floriane Eshak - Paris (France)
"Epitope identification using in-silico approaches, a case study : nanobodies binding to mGlu5 receptor"

11:40 - Jens Carlsson (Department of Cell and Molecular Biology, Uppsala University, Sweden)
"Structure-based discovery of GPCR ligands with tailored pharmacological properties"

12:30 - Awards & Conclusions

12:45 - End of the Meeting

 

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